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Photodynamic therapy for symptomatic oral lichen planus
Debra Fischoff1, Silvia Spivakovsky1
1NYU College of Dentistry, New York, USA.
Evidence-Based Dentistry
|October 27, 2018
Summary
Photodynamic therapy (PDT) offers an effective treatment for oral lichen planus (OLP). This approach helps reduce pain, burning sensations, and lesion size in patients suffering from this condition.
Area of Science:
- Oral medicine
- Dermatology
- Photomedicine
Background:
- Oral lichen planus (OLP) is a chronic inflammatory condition affecting oral mucosa.
- Current treatments, like corticosteroids, have limitations and potential side effects.
Purpose of the Study:
- To evaluate the efficacy of photodynamic therapy (PDT) as a treatment for symptomatic oral lichen planus.
- To compare PDT with conventional corticosteroid therapy for OLP management.
Main Methods:
- A systematic review of randomized controlled trials (RCTs) and non-randomized controlled trials (n-RCTs) was conducted.
- Studies included adult patients with histopathologically confirmed OLP, comparing PDT with corticosteroids.
- Primary outcomes assessed were pain reduction and clinical improvement.
Main Results:
- Five studies (3 RCTs, 2 n-RCTs) with 8-30 participants were included.
- PDT utilized various lasers (diode, LED) and photosensitizers (methylene blue, toluidine blue, 5-aminolevulinic acid).
- Follow-up ranged from one to three months, with results presented narratively.
Conclusions:
- Limited evidence suggests PDT is effective for OLP management.
- PDT demonstrated significant reduction in pain, burning, and lesion size.
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