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Updated: Feb 3, 2026

Live Imaging of Mouse Secondary Palate Fusion
Published on: July 27, 2017
Imaging in secondary tumors of the ovary
Ali Devrim Karaosmanoglu1, Mehmet Ruhi Onur2, Mehmet Coskun Salman3
1Department of Radiology, Faculty of Medicine, School of Medicine, Hacettepe Universitesi Tıp Fakültesi Hastanesi, 06100, Sıhhiye, Ankara, Turkey.
Abstract:
Metastatic involvement of the ovaries is not rare. The most common tumor types metastasizing to the ovaries, from non-gynecological organs, are breast, colorectal, gastric, and appendix tumors. Lymphogenous, hematogenous, and transcoelomic pathways have all been proposed among potential pathways. Early diagnosis and treatment have an important potential to improve the patient outcome. Krukenberg tumors typically appear as complex semisolid masses with varying amounts of solid and cystic components. Ovarian metastases from the colon primaries are predominantly cystic in nature. Secondary lymphomatous involvement of ovary is mostly bilateral and solid with heterogeneous signal intensity on MRI. Metastatic breast cancer to the ovaries is typically bilateral and tends to be of small size. Among all the other imaging characteristics, bilateral involvement of secondary tumors of the ovary appears to be most potentially helpful finding in differentiating from primary ones.
Insights
Metastatic ovarian tumors are common, often originating from breast or colorectal cancers. Bilateral involvement is a key imaging finding that helps differentiate these secondary ovarian tumors from primary ones.
Area of Science:
- Oncology
- Radiology
- Pathology
Background:
- Metastatic involvement of the ovaries is a significant clinical concern.
- Common primary sites include breast, colorectal, gastric, and appendix cancers.
- Potential spread pathways include lymphogenous, hematogenous, and transcoelomic routes.
Purpose of the Study:
- To review the characteristics of common non-gynecological tumors metastasizing to the ovaries.
- To highlight imaging features that aid in differentiating metastatic from primary ovarian tumors.
- To emphasize the importance of early diagnosis and treatment for improved patient outcomes.
Main Methods:
- Review of literature on ovarian metastases from non-gynecological malignancies.
- Analysis of imaging characteristics, including morphology, composition (solid/cystic), and laterality.
- Correlation of imaging findings with primary tumor types.
Main Results:
- Krukenberg tumors (often from colorectal primaries) typically present as complex semisolid masses, predominantly cystic.
- Ovarian metastases from breast cancer are usually bilateral, solid, and small.
- Secondary lymphomatous involvement of the ovary is typically bilateral and solid with heterogeneous MRI signals.
- Bilateral ovarian involvement is a crucial differentiator from primary ovarian neoplasms.
Conclusions:
- Metastatic ovarian tumors have distinct imaging features based on the primary cancer type.
- Bilateral involvement is a highly suggestive sign of secondary ovarian malignancy.
- Accurate differentiation through imaging is essential for appropriate clinical management and prognosis.
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