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Updated: Feb 3, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

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Published on: July 19, 2019

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Association of Multiple Sclerosis with Psoriasis: A Systematic Review and Meta-Analysis of Observational Studies

Chia-Yu Liu1, Tao-Hsin Tung2, Chin-Yu Lee1

  • 1School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei, Taiwan.

American Journal of Clinical Dermatology
|October 27, 2018
PubMed
Abstract

Insights

Individuals with multiple sclerosis (MS) have a higher likelihood of developing psoriasis. This systematic review confirms an increased prevalence and incidence of psoriasis in MS patients.

Area of Science:

  • Dermatology and Neurology
  • Autoimmune Disease Research

Background:

  • Psoriasis and multiple sclerosis (MS) have been observed concurrently in previous studies.
  • Potential shared genetic and pathogenic mechanisms are hypothesized but not fully understood.
  • The precise relationship between psoriasis and MS requires further investigation.

Purpose of the Study:

  • To systematically review and meta-analyze the association between psoriasis and MS.
  • To quantify the odds and risk of psoriasis in individuals diagnosed with MS.

Main Methods:

  • Comprehensive literature search of MEDLINE, Embase, and CENTRAL databases up to July 2018.
  • Inclusion of case-control, cross-sectional, and cohort studies examining psoriasis in MS patients.
  • Meta-analysis using a random-effects model to calculate odds ratios (OR) and hazard ratios (HR).
  • Risk of bias assessment using the Newcastle-Ottawa Scale.

Main Results:

  • Analysis of 11 studies from 10 publications, involving over 18,000 MS patients and 870,000 controls in case-control/cross-sectional studies.
  • Cohort studies included over 25,000 MS patients and 227,000 controls.
  • Significant association found: increased odds of psoriasis in MS patients (OR 1.29; 95% CI 1.14-1.45).
  • Significant association found: increased risk of psoriasis in MS patients (HR 1.92; 95% CI 1.32-2.80).

Conclusions:

  • Patients with multiple sclerosis exhibit a higher prevalence of psoriasis.
  • Individuals with MS also show an increased incidence of developing psoriasis.

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