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Hyperbaric oxygen affects endothelial progenitor cells proliferation in vitro.

Julia C Benincasa1, Luiz H de Freitas Filho1, Giane D Carneiro1

  • 1Department of Structural and Functional Biology, State University of Campinas (UNICAMP), São Paulo, Brazil.

Cell Biology International
|October 27, 2018
PubMed
Summary

Hyperbaric oxygen therapy (HBO) enhances wound healing by promoting cell growth and blood vessel formation. This study shows HBO reduces inflammation in endothelial cells, aiding vascular recovery.

Keywords:
cell therapyendothelial progenitor cellhyperbaric oxygeninflammationtumor necrosis factor-alphawound healing

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Vascular Biology

Background:

  • Hyperbaric oxygen (HBO) treatment aids wound healing through increased fibroblast proliferation, collagen synthesis, and angiogenesis.
  • HBO may enhance endothelial progenitor cell (EPC) mobilization and vessel healing via nitric oxide pathways.
  • The precise cellular mechanisms of HBO's effects on EPC proliferation and activation are not fully understood.

Purpose of the Study:

  • To investigate the effects of HBO on the proliferation of bone marrow-derived EPCs pre-treated with TNF-alpha.
  • To analyze changes in ICAM and eNOS expression, reactive oxygen species production, and in vitro wound healing after HBO treatment.

Main Methods:

  • Bone marrow-derived EPCs were pre-treated with TNF-alpha.
  • Cells were subjected to 1-hour hyperbaric oxygen treatment.
  • Immunochemistry was used to assess ICAM and eNOS expression.
  • Reactive oxygen species production and in vitro wound closure were measured.

Main Results:

  • HBO treatment did not significantly alter in vitro wound closure or EPC proliferation rates.
  • HBO significantly increased eNOS expression in TNF-alpha pre-treated EPCs.
  • HBO decreased ICAM expression and reactive oxygen species production.
  • HBO mitigated the inflammatory response induced by TNF-alpha in endothelial cells.

Conclusions:

  • HBO treatment can reduce TNF-alpha-mediated inflammatory responses in endothelial cells.
  • These findings suggest HBO promotes vascular recovery after injury by modulating cellular inflammatory pathways.
  • Further research into HBO's cellular mechanisms is warranted to optimize therapeutic applications.