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Nonaspirin NSAIDs and contralateral breast cancer risk

Annet Bens1, Deirdre Cronin-Fenton2, Christian Dehlendorff3

  • 1Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.

International Journal of Cancer
|October 27, 2018
PubMed

Insights

Postdiagnosis use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) did not reduce the risk of contralateral breast cancer (CBC) in Danish patients. This finding applies regardless of whether the NSAIDs were cyclooxygenase (COX)-2 selective or nonselective.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Laboratory studies indicate cyclooxygenase (COX)-2 inhibition may suppress breast cancer development.
  • Nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) include COX-2 selective and nonselective agents.

Purpose of the Study:

  • To investigate if postdiagnosis use of nonaspirin NSAIDs impacts contralateral breast cancer (CBC) risk in Danish breast cancer patients.
  • To differentiate the effects of COX-2 selective versus nonselective NSAIDs on CBC risk.

Main Methods:

  • A nationwide cohort study of 52,723 Danish breast cancer patients diagnosed between 1996 and 2012.
  • Utilized nationwide registries for data on NSAID use, CBC diagnosis, and confounding variables.
  • Employed Cox proportional hazard regression models to analyze the association between postdiagnosis NSAID use and CBC risk, with a one-year lag.

Main Results:

  • Overall postdiagnosis nonaspirin NSAID use showed an adjusted hazard ratio (HR) of 0.98 (95% CI: 0.87-1.11) for CBC.
  • No substantial variation in HRs was observed with NSAID use duration or intensity.
  • Both COX-2 selective (HR: 1.02; 95% CI: 0.85-1.23) and nonselective (HR: 0.96; 95% CI: 0.82-1.13) nonaspirin NSAIDs demonstrated similar non-significant associations with CBC risk.

Conclusions:

  • This nationwide cohort study suggests that postdiagnosis use of nonaspirin NSAIDs does not reduce the risk of contralateral breast cancer.
  • The findings indicate no significant difference in CBC risk reduction between COX-2 selective and nonselective nonaspirin NSAIDs.
Keywords:
contralateral breast cancernonaspirin NSAIDspharmacoepidemiologyprevention

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