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The eukaryotic promoter region is a segment of DNA located upstream of a gene. It contains an RNA polymerase binding site, a transcription start site, and several cis-regulatory sequences.  The proximal promoter region is located in the vicinity of the gene and has cis-regulatory sequences and the core promoter. The core promoter is the binding site for RNA polymerase and is usually located between -35 and +35 nucleotides from the transcription start site. The distal promoter regions are...
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Related Experiment Video

Updated: Feb 3, 2026

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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CYLD deficiency promotes pancreatic cancer development by causing mitotic defects.

Songbo Xie1, Yuhan Wu1, Huijie Hao2

  • 1College of Life Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, Institute of Biomedical Sciences, Shandong Normal University, Jinan, Shandong, China.

Journal of Cellular Physiology
|October 27, 2018
PubMed
Summary

Cylindromatosis (CYLD) suppresses pancreatic cancer growth by ensuring correct cell division. Reduced CYLD expression correlates with poor outcomes, suggesting CYLD as a potential early detection biomarker.

Keywords:
chromosome missegregationcylindromatosis (CYLD)pancreatic cancerspindle misorientationtumorigenesis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Pancreatic cancer has a high mortality rate, necessitating early detection methods.
  • Identifying proteins involved in cancer progression can yield valuable biomarkers.

Purpose of the Study:

  • To investigate the role of cylindromatosis (CYLD) in pancreatic cancer development.
  • To evaluate CYLD as a potential biomarker for early detection and prognosis.

Main Methods:

  • Analysis of CYLD gene copy number and expression in pancreatic cancer samples.
  • In vitro and in vivo studies assessing the impact of CYLD deficiency on tumor growth.
  • Mechanistic studies on CYLD's role in cell division and chromosome segregation.

Main Results:

  • Downregulation of CYLD expression in pancreatic cancer linked to gene copy number loss.
  • Reduced CYLD expression correlated negatively with clinicopathological parameters.
  • CYLD deficiency promoted colony formation and tumor growth, increasing chromosome missegregation.

Conclusions:

  • CYLD acts as a tumor suppressor in pancreatic cancer.
  • CYLD's role in cell division is critical for preventing tumorigenesis.
  • CYLD is a potential biomarker for early detection and prognosis in pancreatic cancer.