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Related Concept Videos

CRISPR01:59

CRISPR

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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CRISPR and crRNAs02:53

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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Electrical Current01:10

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Electrical current is defined as the rate at which charge flows. When there is a large current present, such as that used to run a refrigerator, a large amount of charge moves through the wire in a small amount of time. If the current is small, such as that used to operate a handheld calculator, a small amount of charge moves through the circuit over a long period of time. The SI unit for current is the ampere (A), named for the French physicist André-Marie Ampère (1775–1836).
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Current Density01:21

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The total amount of current flowing through one unit value of a cross-sectional area is referred to as current density. If the current flow is uniform, the amount of current flowing through a conductor is the same at all points along the conductor, even if the conductor area varies. The current density consists of the local magnitude and direction of the charge flow, which varies from point to point. Current density is measured in amperes per meter square, and direction is defined as the net...
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Since eddy currents occur only in conductors, magnets can separate metals from other materials. For example, in a recycling center, trash is dumped in batches down a ramp, beneath which lies a powerful magnet. Conductors in the trash are slowed by eddy currents, while nonmetals in the trash move on, separating from the metals. This works for all metals, not just ferromagnetic ones.
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Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases
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Author Spotlight: Development of Simplified CRISPR-Based Tests for Rapid Detection of Infectious Diseases

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Current progress in CRISPR-based diagnostic platforms.

Khushal Khambhati1, Gargi Bhattacharjee1, Vijai Singh1

  • 1Department of Microbiology, Synthetic Biology Laboratory, School of Biological Sciences and Biotechnology, Institute of Advanced Research, Gandhinagar, India.

Journal of Cellular Biochemistry
|October 27, 2018
PubMed
Summary
This summary is machine-generated.

CRISPR-Cas technology offers a powerful new method for rapid, sensitive, and specific pathogen detection. This genome editing system, when integrated with lateral flow assays, provides a versatile diagnostic tool for infectious diseases, cancer, and genetic disorders.

Keywords:
Cas13aattomolarclustered regularly interspaced short palindromic repeats-based diagnosticepidemic diseasesguide-RNAmultiplex

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Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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Area of Science:

  • Molecular Biology
  • Biotechnology
  • Medical Diagnostics

Background:

  • CRISPR-Cas systems are fundamental tools for genome editing and regulation across diverse organisms.
  • CRISPR-Cas-based platforms are emerging as highly promising for sensitive pathogen detection.

Purpose of the Study:

  • To highlight the potential of integrating CRISPR-Cas technology with lateral flow systems for advanced diagnostics.
  • To underscore the versatility of this combined approach for detecting various diseases.

Main Methods:

  • Integration of CRISPR-Cas gene editing components with lateral flow assay (LFA) technology.
  • Development of rapid, sensitive, and specific detection assays.

Main Results:

  • The combined CRISPR-Cas and LFA platform demonstrates ideal properties for diagnostic applications.
  • This approach enables cost-effective and reliable detection.

Conclusions:

  • CRISPR-Cas integrated with lateral flow systems offers a frontline diagnostic solution.
  • Potential applications include pathogen detection during outbreaks, cancer screening, and genetic disease diagnosis.