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Updated: Feb 3, 2026

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
Published on: November 28, 2010
Ovarian cancer: Pathogenesis and current recommendations for prophylactic surgery
I Nyoman Gede Budiana1, Michelle Angelina1, Tjokorda Gede Astawa Pemayun1
1Department of Obstetrics and Gynecology, Udayana University Sanglah General Hospital Faculty of Medicine, Bali, Indonesia
Abstract:
Ovarian cancer is one of the most common gynecologic cancers, and one of the leading causes of cancer-associated female mortality in the world. Currently, no widely accepted pathogenesis is available, which may explain the entire disease. Early detection and primary prevention of ovarian cancer are difficult, mostly due to its heterogeneous nature. Risk factor modification based on epidemiologic data has not significantly reduced the incidence of ovarian cancer. Currently, prophylactic surgical methods have been proposed as the most effective preventive measures for both the high-risk or low-risk populations. Understanding the existing pathogenesis theories and the surgical options available may alter physician’s perspectives and facilitate better decision making.
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