Related Experiment Video
Updated: Feb 3, 2026
09:27
How to Culture, Record and Stimulate Neuronal Networks on Micro-electrode Arrays MEAs
Published on: May 30, 2010
55.9K
Cyclomatrix Polyphosphazene Porous Networks with J-Aggregated Multiphthalocyanine Arrays for Dual-Modality
Jing Tan1, Jittima Meeprasert2, Yuxue Ding1
1State Key Laboratory of Molecular Engineering of Polymers, and Department of Macromolecular Science , Fudan University , Shanghai 200433 , P. R. China.
ACS Applied Materials & Interfaces
|October 27, 2018
Summary
New cyclomatrix polyphosphazenes function as organic photosensitizers for dual-modality phototherapy. These nanoparticles efficiently kill cancer cells using photothermal and photodynamic therapy upon near-infrared laser irradiation.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Organic photosensitizers are crucial for phototherapy.
- Developing efficient and biocompatible photosensitizers remains a challenge.
Purpose of the Study:
- To develop novel cyclomatrix polyphosphazenes as organic photosensitizers for dual-modality phototherapy.
- To investigate their photophysical properties and efficacy in cancer treatment.
Main Methods:
- Synthesis of Zn(II) phthalocyanine (ZnPc)-based cyclomatrix polyphosphazenes using hexachlorocyclophosphazene (HCCP).
- Molecular simulation to predict molecular arrangement and optical properties.
- Assembly into nanoparticles with polyvinylpyrrolidone (PVP) for aqueous dispersibility and biocompatibility.
- In vitro evaluation of photothermal and photodynamic therapeutic efficacy using a near-infrared (NIR) laser.
Main Results:
- The synthesized polyphosphazenes exhibit excellent photophysical properties with red-shifted and intense NIR absorbance.
- PVP-stabilized nanoparticles demonstrated good aqueous dispersibility and biocompatibility.
- Effective killing of cancer cells was achieved through combined photothermal and photodynamic effects upon NIR laser irradiation.
- The dense and oriented arrangement of ZnPc molecules within the polyphosphazene framework significantly enhanced photophysical and photochemical properties.
Conclusions:
- Cyclomatrix polyphosphazenes represent a promising platform for developing advanced organic photosensitizers.
- This new class of materials shows significant potential for dual-modality phototherapy applications in cancer treatment.
Keywords:
conjugated porous polymersmetallophthalocyaninenear-infrared lightphotothermal/photodynamic therapypolyphosphazeneMore Related Videos
08:32Examining Online Syntactic Processing of Spoken Complex Sentences in Chinese Using Dual-Modal Interference Tasks
Published on: September 5, 2019
5.9K
09:20Novel Photoacoustic Microscopy and Optical Coherence Tomography Dual-modality Chorioretinal Imaging in Living Rabbit Eyes
Published on: February 8, 2018
11.4K
Related Concept Videos
01:15Sensory Modalities
3.9K
Sensation typically is the process by which the sensory receptors and sense organs detect stimuli from the internal and external environment and transmit this information to the central nervous system for processing.
General senses refer to the broad category of sensory information detected by receptors in the body and can be further grouped into somatic and visceral senses. Somatic sensations include touch, pressure, temperature, and pain and are essential for navigating our environment and...
General senses refer to the broad category of sensory information detected by receptors in the body and can be further grouped into somatic and visceral senses. Somatic sensations include touch, pressure, temperature, and pain and are essential for navigating our environment and...
3.9K
02:26Protein Networks
4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
02:26Protein Networks
2.9K
2.9K
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
01:29Aggregates Classification
1.0K
Aggregate classification is generally based on its size, petrographic characteristics, weight, and source. Size classification ranges from coarse to fine aggregates, defined by the size of the particles. Coarse aggregates are particles that do not pass through ASTM sieve No. 4, and aggregates that pass through the sieve are fine aggregates.
Petrographic classification groups aggregates based on common mineralogical characteristics. Some of the common mineral groups found in aggregates are...
Petrographic classification groups aggregates based on common mineralogical characteristics. Some of the common mineral groups found in aggregates are...
1.0K
01:09Infrared (IR) Spectroscopy: Overview
5.1K
When electromagnetic radiation passes through a material, atoms or molecules transition from a lower to a higher energy state by absorbing radiation corresponding to the energy difference between the two states. The absorption of infrared (IR) radiation causes transitions between vibrational energy levels in a molecule. Therefore, IR spectroscopy is a useful analytical tool for determining the molecular structure of molecules.
Different compounds display unique properties due to their...
Different compounds display unique properties due to their...
5.1K