Related Experiment Video
Updated: Feb 3, 2026

Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus
Published on: December 7, 2013
Isolated fungus ball in sphenoid sinus: tips and pitfalls of T 1 hyperintense lesions
Teresa Popolizio1, Marco Perri1, Rosario Francesco Balzano2
1Department of Radiology, Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Puglia, Italy.
Abstract:
Isolated sphenoid sinus fungus ball is a very rare condition. CT is the most used imaging investigation for diagnosis. In some cases, MRI may provide further information to evaluate the extracompartmental invasion. We report the case of an elderly female patient who presented with headache and a soft tissue mass filling the right sphenoid sinus on CT, misdiagnosed as simple sinusitis. After 1 year, with recrudescence of symptoms, brain MRI showed a hyperintense soft tissue mass on T 1 weighted images within the right sphenoidal sinus; a new CT examination revealed calcifications within the mass. Surgical histological examination showed fungus ball. Fungal ball should be included in the differential diagnosis of T 1 hyperintense lesions in the sphenoid sinus.
Insights
Isolated sphenoid sinus fungus balls are rare. This case highlights the importance of considering fungal balls in T1 hyperintense sphenoid sinus lesions, even after initial misdiagnosis.
Area of Science:
- Otolaryngology
- Radiology
- Pathology
Background:
- Isolated sphenoid sinus fungus ball is an exceptionally rare clinical diagnosis.
- Computed tomography (CT) and magnetic resonance imaging (MRI) are crucial for diagnosing sphenoid sinus pathologies.
- Evaluating extracompartmental invasion often requires advanced imaging techniques like MRI.
Observation:
- An elderly female presented with headache and a sphenoid sinus mass initially diagnosed as sinusitis via CT.
- Recurrence of symptoms after one year prompted a brain MRI, revealing a T1 hyperintense lesion.
- A subsequent CT scan identified calcifications within the mass, leading to surgical investigation.
Findings:
- Histopathological examination confirmed the presence of a fungal ball within the sphenoid sinus.
- The lesion was initially misdiagnosed due to its presentation mimicking simple sinusitis.
- MRI T1-weighted imaging revealed characteristic hyperintensity of the soft tissue mass.
Implications:
- Fungal balls should be included in the differential diagnosis for T1 hyperintense lesions within the sphenoid sinus.
- This case underscores the utility of MRI in characterizing complex sphenoid sinus masses.
- Accurate and timely diagnosis of sphenoid sinus fungal balls is essential for appropriate patient management.
Related Concept Videos
ECG Interpretation of Arrhythmias I: Sinus Arrhythmias
Types of Arrhythmias
Sinus Node Arrhythmias
Sinus Bradycardia: Originating from the sinoatrial (SA) node, sinus bradycardia involves slower impulses, resulting in a heart rate of less than 60 beats per minute (bpm). Causes include sleep, vagal stimulation, beta-blockers, hypothyroidism,...
DNA Isolation
DNA Isolation
Overview Of Cell Separation And Isolation
Cyclic Processes And Isolated Systems
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state.
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
Techniques for Isolation of Pure Cultures

