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Extensive pericardial calcification secondary to radiotherapy, causing mixed constrictive-restrictive pathology
Miguel Paniagua González1, María Luisa Sánchez Alegre1
1Radiology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
BJR Case Reports
|October 27, 2018
Summary
Childhood neuroblastoma treatment led to extensive cardiac calcifications. This resulted in a mixed constrictive and restrictive cardiac pathology, impacting the patient's heart function.
Area of Science:
- Cardiology
- Pediatric Oncology
- Cardiac Surgery
Background:
- Mediastinal neuroblastoma is a rare cancer primarily affecting children.
- Treatment for neuroblastoma often involves surgery, chemotherapy, and radiotherapy.
- Long-term sequelae of childhood cancer treatment require ongoing monitoring.
Observation:
- A patient treated for mediastinal neuroblastoma in 1977 developed cardiac complications.
- Calcifications were observed in multiple cardiac structures, including atrial walls, interatrial septum, right ventricular free wall, mitral and aortic valves, and pericardium.
Findings:
- The cardiac calcifications resulted in a mixed constrictive and restrictive cardiac pathology.
- This pathology significantly impacted the patient's cardiac function and hemodynamics.
Implications:
- Highlights the potential for late-onset cardiac complications following childhood cancer therapy.
- Underscores the importance of long-term cardiovascular surveillance in neuroblastoma survivors.
- Suggests a need for further research into the mechanisms of radiation-induced cardiac calcification.
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