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High-grade malignant pancreatic neoplasm with sarcomatoid features
Natesh Yepuri1, Napat Pruekprasert1, Rana Naous2
1Department of Surgery, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
AME Case Reports
|October 27, 2018
Summary
Sarcomatoid carcinoma of the pancreas (SCP) is a rare, aggressive cancer. This case highlights its incidental discovery and rapid, widespread metastasis, emphasizing the need for early detection.
Area of Science:
- Oncology
- Pathology
Background:
- Sarcomatoid carcinoma is a rare, aggressive malignancy with diverse presentations.
- Pancreatic sarcomatoid carcinoma (SCP) is exceptionally rare, with poorly understood pathogenesis.
- Microscopically, SCP exhibits an anaplastic, sarcoma-like appearance with spindle cell predominance.
Observation:
- A case of pancreatic sarcomatoid carcinoma was incidentally discovered via CT scan for chronic back pain.
- Imaging revealed a pancreatic mass, liver lesion, bilateral lung nodules, and vertebral metastases.
- Endoscopic ultrasound-guided liver biopsy confirmed high-grade malignant pancreatic neoplasm with sarcomatoid features.
Findings:
- The patient presented with advanced, widely metastatic disease.
- The tumor showed high-grade malignant features with sarcomatoid differentiation.
- Despite diagnosis, the patient declined treatment and had a rapid decline.
Implications:
- This case underscores the aggressive nature and potential for rapid metastasis of SCP.
- Highlights the importance of considering rare diagnoses in unexplained symptoms.
- Emphasizes the diagnostic role of advanced imaging and biopsy in complex cases.
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