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Wilms' tumor: prognostic factors and survival
Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
|April 1, 1987
Summary
This study on Wilms' tumor found that early-stage diagnosis and younger age significantly improve survival rates. Advanced stages and older age correlated with poorer outcomes in pediatric oncology patients.
Area of Science:
- Pediatric Oncology
- Clinical Statistics
- Cancer Research
Background:
- Wilms' tumor is a significant pediatric malignancy.
- Understanding prognostic factors is crucial for treatment strategies.
Purpose of the Study:
- To analyze survival rates and prognostic factors in pediatric Wilms' tumor cases.
- To investigate the correlation between clinical parameters and patient outcomes.
Main Methods:
- Statistical analysis of 38 Wilms' tumor cases treated between 1977-1984.
- Evaluation of factors including tumor stage, patient age, symptoms, localization, and histological grade.
Main Results:
- Overall two-year survival rate was 67%, and five-year survival was 63%.
- Early stages (I & II) with a median age of 16 months showed an 87% two-year survival.
- Advanced stages with a median age of 5 years had a 43% two-year survival.
- No correlation found between survival and initial symptoms or tumor localization.
Conclusions:
- Tumor stage and patient age are critical prognostic indicators for Wilms' tumor.
- Early detection and treatment in pediatric patients are vital for improving survival rates.