Related Experiment Videos
Characterizing Premotor Parkinson's Disease: Clinical Features and Objective Markers.
Lama M Chahine1, Matthew B Stern1
1Penn Parkinson's Disease and Movement Disorders Center Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA.
Movement Disorders Clinical Practice
|October 27, 2018
Summary
Early identification of Parkinson's disease (PD) is crucial. This review explores nonmotor symptoms and objective markers for detecting the premotor phase of PD before motor symptoms appear.
Area of Science:
- Neurology
- Neuroscience
- Movement Disorders
Background:
- Parkinson's disease (PD) diagnosis typically occurs after motor symptom onset.
- Early intervention strategies require identification of PD in preclinical and premotor stages.
- The premotor phase is characterized by detectable nonmotor symptoms.
Purpose of the Study:
- To review candidate nonmotor features indicative of the premotor phase of Parkinson's disease.
- To discuss potential objective measures for assessing the premotor phase of PD.
- To highlight the need for a multi-modal approach in early PD detection.
Main Methods:
- Literature review of nonmotor manifestations in Parkinson's disease.
- Analysis of objective diagnostic markers for the premotor phase.
- Discussion of electrophysiologic and imaging techniques.
Main Results:
- Nonmotor symptoms include olfactory, neuropsychiatric, sleep, gastrointestinal, and autonomic changes.
- Objective measures like dopaminergic imaging show potential for early PD detection.
- A combination of assessments is necessary for high sensitivity and specificity.
Conclusions:
- Defining the premotor phase of PD is essential for future therapeutic interventions.
- Nonmotor symptoms and objective markers are key to identifying individuals at risk.
- Further research is needed to validate these markers for clinical use.