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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

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Published on: March 8, 2022

Bednar Tumour Occurring after Malignant Melanoma Excision.

Amedeo Ferlosio¹, Monia Di Prete¹, Piero Rossi²

¹Anatomic Pathology, University of Rome Tor Vergata, Viale Oxford 81, 00133 Rome, Italy.

Case Reports in Pathology

|October 27, 2018

Summary

A rare Bednar tumour, a pigmented variant of dermatofibrosarcoma protuberans, was diagnosed in a patient with prior melanoma. This case highlights the importance of differentiating pigmented skin lesions, especially near melanoma scars.

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Area of Science:

Dermatopathology
Surgical Oncology
Oncologic Imaging

Background:

Melanoma is a significant skin cancer with potential for metastasis.
Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive skin sarcoma.
Bednar tumour is an uncommon pigmented variant of DFSP.

Observation:

A 74-year-old man presented with a slow-growing mass near a prior melanoma excision scar.
Initial clinical diagnosis suggested melanoma metastasis.
Histopathology revealed a dermal spindle cell proliferation with pigment-containing dendritic cells.

Findings:

Immunohistochemistry confirmed spindle cell positivity for CD34 and vimentin.
Dendritic cells stained positive for S100, Melan-A, and HMB-45.
A final diagnosis of Bednar tumour was established.

Implications:

Bednar tumour requires careful differential diagnosis from other pigmented skin neoplasms.
The proximity to a melanoma scar raises questions about the origin of pigmented cells.
Understanding Bednar tumour's characteristics is crucial for accurate diagnosis and patient management.