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Current Role of Chemotherapy in Nonmetastatic Nasopharyngeal Cancer
Tapesh Bhattacharyya1, Geethu Babu2, Cessal Thommachan Kainickal2
1Division of Radiation Oncology, Tata Medical Center, Kolkata, India.
Abstract:
Nasopharyngeal carcinoma is highly radio- and chemosensitive tumor with its unique clinical and biological behavior. Treatment of stage I disease is radical radiotherapy alone. For stage II disease treatment is radiotherapy with or without chemotherapy. The standard of care for locally advanced nasopharyngeal cancer (stages III-IVB) is concurrent chemoradiation. Optimum timing and sequence of chemotherapy are not yet well-defined. The role of adjuvant and induction chemotherapy is debatable. Here we are going to highlight the role of chemotherapy in nasopharyngeal carcinoma, its benefit, and controversies regarding timing and sequences.
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