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Antiapoptotic Molecule Survivin in Transplantation: Helpful or Harmful?

Sara Assadiasl1, Mohammad Javad Mousavi2,3, Aliakbar Amirzargar1,2

  • 1Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Transplantation
|October 27, 2018
PubMed

Insights

Survivin, an anti-apoptotic protein, shows potential for improving graft survival in transplantation by protecting tissues from damage. However, concerns exist regarding its cancer-inducing risks and impact on immune rejection.

Area of Science:

  • Biochemistry
  • Immunology
  • Transplantation Science

Background:

  • Survivin is an antiapoptotic protein belonging to the inhibitor of apoptosis protein (IAP) family.
  • It is recognized for its role in cancer, with therapeutic and diagnostic applications explored in oncology.
  • Survivin's cytoprotective properties suggest potential benefits in preserving tissue viability.

Purpose of the Study:

  • To review the existing studies on survivin's effects on graft survival.
  • To evaluate the potential advantages of using survivin in transplantation.
  • To identify the disadvantages and risks associated with survivin overexpression in transplant contexts.

Main Methods:

  • Literature review of studies investigating survivin in transplantation.
  • Analysis of survivin's role in protecting allografts from ischemia reperfusion injury and inflammation.
  • Assessment of survivin's impact on immune responses, including lymphocyte development and proliferation.

Main Results:

  • Survivin demonstrates potential in protecting transplanted organs from damage.
  • Concerns regarding survivin's oncogenic potential and its influence on adaptive immunity are highlighted.
  • The molecule's involvement in lymphocyte proliferation may increase the risk of graft rejection.

Conclusions:

  • Survivin presents a dual role in transplantation, offering cytoprotection but posing risks of malignancy and immune rejection.
  • Further research is needed to balance the benefits and risks of survivin application in clinical transplantation.
  • Careful consideration of survivin's impact on both the graft and the host immune system is crucial for its therapeutic use.

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