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Related Experiment Videos

Shaping Diversity Into the Brain's Form and Function.

Lauren N Miterko1,2,3, Elizabeth P Lackey1,3,4, Detlef H Heck5

  • 1Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, United States.

Frontiers in Neural Circuits
|October 27, 2018
PubMed
Summary
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Brain structure and function are intricately linked, with dynamic processes shaping brain regions into specific patterns. These patterns optimize signal processing and information integration for cognitive development, even in disorders like autism spectrum disorder.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Computational Biology

Background:

  • The brain exhibits remarkable cellular diversity and complex connectivity, underpinning specialized functions.
  • Gross external morphologies, like cortical and cerebellar folds, are characteristic of brain regions.
  • The relationship between brain structure, function, and spatial scale remains an area of active investigation.

Purpose of the Study:

  • To explore the mechanisms sculpting functional brain maps and external morphologies.
  • To investigate the link between structure and function across different spatial scales.
  • To contrast structural defects in neurodevelopmental disorders and their impact on cognitive development.

Main Methods:

  • Discussion of developmental mechanisms.
Keywords:
connectivityfoldingglialayeringneuronpatterningtopography

Related Experiment Videos

  • Comparative analysis of brain morphology and function.
  • Consideration of genetic and environmental factors in neurodevelopmental disorders.

    • Main Results:

    • Dynamic processes shape all brain areas into organized, "jigsaw-like" patterns.
    • Regional patterns reflect underlying circuit connectivity.
    • These patterns are crucial for local signal processing and multi-areal information integration.

    Conclusions:

    • Brain structure and function are deeply intertwined, with morphology reflecting connectivity.
    • Optimized brain function relies on the integration of information across specialized regions.
    • Understanding these principles is vital for comprehending neurodevelopmental disorders.