Related Experiment Video
Updated: Feb 3, 2026

Isolation of Intact, Whole Mouse Mammary Glands for Analysis of Extracellular Matrix Expression and Gland Morphology
Published on: October 30, 2017
Increased p63 Expression in Canine Perianal Gland Tumours
Soo-Hyeon Kim1, Byung-Joon Seung1, Seung-Hee Cho1
1Small Animal Tumour Diagnostic Centre, Department of Veterinary Pathology, Konkuk University, 05029, Seoul, Republic of Korea.
Introduction:
p63 is a homologous molecule of p53 and was recently identified as playing important roles in several key cellular processes, including epithelial development and proliferation. Since then, several studies have demonstrated altered p63 expression in various cancers of epithelial origin. Canine perianal gland tumour is one of the most common skin neoplasms in dogs; however, the molecular characteristics of this tumour remain poorly understood. The objective of the present study was to analyse and compare the expression of p63 in canine perianal gland adenomas and carcinomas.
Material And Methods:
Haematoxylin and eosin-stained slides were examined and immunohistochemistry was conducted for a total of 65 samples. Immunohistochemical data for p63 expressions were compared between groups using the Mann-Whitney U test.
Results:
The p63 expression level was increased in perianal gland carcinomas compared to that in the adenoma samples (P < 0.0001). The percentage of cells expressing p63 was higher in perianal gland carcinomas than in adenomas, although the intensity of immunostaining did not differ significantly between the two groups.
Conclusion:
p63 is a candidate factor contributing to the malignant transformation and progression of canine perianal gland tumours.
Related Concept Videos
Increasing Function
Increased Body Temperature
Increased pulse rate
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
Exocrine Glands: Unicellular and Multicellular Glands
The Pituitary Gland
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...

