Related Experiment Video
Updated: Feb 3, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
BREAST CANCER HISTOPATHOLOGY IMAGE ANALYSIS PIPELINE FOR TUMOR PURITY ESTIMATION
Vahid Azimi1, Young Hwan Chang1, Guillaume Thibault1
1Oregon Health and Science University (OHSU).
Abstract:
The translation of genomic sequencing technology to the clinic has greatly advanced personalized medicine. However, the presence of normal cells in tumors is a confounding factor in genome sequence analysis. Tumor purity, or the percentage of cancerous cells in whole tissue section, is a correction factor that can be used to improve the clinical utility of genomic sequencing. Currently, tumor purity is estimated visually by expert pathologists; however, it has been shown that there exist vast inter-observer discrepancies in tumor purity scoring. In this paper, we propose a quantitative image analysis pipeline for tumor purity estimation and provide a systematic comparison between pathologists' scores and our image-based tumor purity estimation.
Related Concept Videos
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer Survival Analysis
What are Estimates?
The estimate for the mean of a sample is denoted by ͞x, whereas the mean of the population is designated as μ. Further, parameters such...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Estimation of k and VD of Aminoglycosides
Estimation of the Physical Quantities

