Comparative in vitro activity of the new cyclic lipopeptide LY146032 against Corynebacterium species

Agar dilution and time-kill techniques were used to assess the in vitro activity of LY146032 and several other antibacterial agents against Corynebacterium spp. The activity of LY146032 was similar to that of vancomycin and teicoplanin. Synergistic killing by a combination of LY146032 and gentamicin could be demonstrated under certain carefully controlled conditions.