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ADMA and NT pro-BNP are associated with overall mortality in elderly

Safoura Sheikh Rezaei1, Stefan Weisshaar1, Brigitte Litschauer1

  • 1Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

European Journal of Clinical Investigation
|October 27, 2018
PubMed

Insights

Asymmetrical dimethylarginine (ADMA) and NT pro-BNP are early mortality risk markers in geriatric patients. Increased levels of these markers, along with male sex and older age, predict mortality in this population.

Area of Science:

  • Geriatric Medicine
  • Cardiovascular Disease Research
  • Biomarker Discovery

Background:

  • Elevated asymmetrical dimethylarginine (ADMA) and NT pro-BNP are linked to mortality in cardiovascular disease and general populations.
  • Prognostic value of these markers in older adults remains under-investigated.
  • Geriatric care patients represent a unique population for assessing mortality risk factors.

Purpose of the Study:

  • To evaluate the prognostic significance of various factors, including laboratory markers, in predicting mortality among geriatric care patients.
  • To establish the role of ADMA and NT pro-BNP as mortality predictors in an elderly cohort.
  • To identify key clinical and demographic predictors of survival in long-term geriatric care.

Main Methods:

  • Prospective observational single-center cohort study.
  • Collection of blood samples for ADMA, NT pro-BNP, SDMA, L-arginine, and CRP.
  • Mortality follow-up up to 90 months, analyzed using Spearman correlation and Cox proportional hazard models.

Main Results:

  • Analysis included 449 geriatric care patients, with 381 deaths during follow-up.
  • Significant mortality predictors identified: male sex, older age, lower BMI, neuroleptic medication use, peripheral artery disease, and elevated ADMA, NT pro-BNP, and CRP.
  • Cox regression analysis confirmed these factors as significant predictors.

Conclusions:

  • Asymmetrical dimethylarginine (ADMA) and NT pro-BNP concentrations serve as early risk markers for overall mortality in geriatric care settings.
  • Use of neuroleptic medication is associated with increased mortality risk in this elderly population.
  • These findings support the utility of specific biomarkers and clinical factors for risk stratification in geriatric patients.
Abstract

Keywords:
ADMAgeriatric careoverall mortalityrisk markers

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