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Updated: Feb 3, 2026
10:26
Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
13.0K
Dendritic cells and their relation to apical peridontitis
José Antonio Poli de Figueiredo1, Audrey Moraes Machado2, Vinícius Pasqualotti de Oliveira2
1Universidade Federal do Rio Grande do Sul - UFRGS, School of Dentistry, Department of Morphological Sciences, Porto Alegre, RS, Brazil.
Brazilian Oral Research
|October 27, 2018
Summary
This study explores the link between apical periodontitis biofilms and dendritic cells (DCs). Findings suggest DCs in periapical lesions may indicate disease severity and constant antigen presence.
Area of Science:
- Immunology
- Oral Biology
- Endodontics
Background:
- Apical periodontitis involves inflammation at the root apex.
- Apical biofilms are complex microbial communities.
- Dendritic cells (DCs) are key immune regulators.
Purpose of the Study:
- To re-examine apical periodontitis, apical biofilms, and their relationship with dendritic cells.
- To investigate the role of DCs in periapical inflammatory lesions.
Main Methods:
- Analysis of root apexes using Scanning Electron Microscopy (SEM) after apicoectomy.
- Identification of microbial biofilms and cellular components in periapical lesions.
Main Results:
- Multispecies microbial biofilms and Howship lacunae indicative of resorption were observed.
- Images suggestive of dendritic cells were identified in periapical lesions.
- The presence of DCs may correlate with lesion severity and antigen exposure.
Conclusions:
- Dendritic cells are present in periapical inflammatory lesions.
- DCs may play a role in modulating the immune response to apical periodontitis.
- Further research is needed to fully elucidate the function of DCs in this context.
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