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Diagnosis and management of hypercalcemia associated with silicone-induced granuloma

Majdi Hamadeh1, Jawad Fares2

  • 1Department of Nephrology and Hypertension, Al-Zahraa University Hospital, Beirut, Lebanon.

Revista Da Associacao Medica Brasileira (1992)
|October 27, 2018
PubMed

Insights

Silicone-induced granuloma can cause hypercalcemia, a rare condition diagnosed after excluding other causes. Management requires personalized treatment, as seen in a bodybuilder with nephrocalcinosis requiring dialysis and corticosteroids.

Area of Science:

  • Endocrinology
  • Nephrology
  • Plastic Surgery

Background:

  • Hypercalcemia is a complex condition with numerous potential causes.
  • Silicone injections for body contouring are increasingly popular, raising awareness for potential complications.
  • Silicone-induced granuloma is a rare but serious adverse effect associated with cosmetic procedures.

Observation:

  • A male patient with multiple silicone injections developed hypercalcemia and urinary symptoms.
  • Diagnostic workup ruled out common causes of hypercalcemia.
  • CT imaging revealed nephrocalcinosis, and biopsy confirmed granulomatous inflammation.

Findings:

  • The patient required dialysis and corticosteroid treatment for symptom relief and laboratory normalization.
  • This case highlights the diagnostic challenges and management strategies for silicone-induced hypercalcemia.
  • Nephrocalcinosis was a significant finding in this patient.

Implications:

  • Clinicians should consider silicone-induced hypercalcemia in patients with unexplained hypercalcemia and a history of cosmetic injections.
  • Early diagnosis and appropriate management are crucial to prevent severe complications.
  • The rising trend in body enhancement procedures necessitates increased vigilance for rare complications like silicone-induced granuloma.

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