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Methoxetamine: A foe or friend?

Chrislean Jun Botanas1, June Bryan de la Peña2, Hee Jin Kim1

  • 1Uimyung Research Institute for Neuroscience, Department of Pharmacy, Sahmyook University, 815 Hwarangro, Nowon-gu, Seoul, 01795, Republic of Korea.

Neurochemistry International
|October 27, 2018
PubMed

Insights

Methoxetamine (MXE), an NMDA receptor antagonist, shows potential antidepressant and analgesic effects despite risks of misuse. Further research is needed to understand its complex psychopharmacological properties and therapeutic potential.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Methoxetamine (MXE) is an NMDA receptor antagonist with similarities to ketamine and phencyclidine.
  • Reports indicate MXE misuse can lead to adverse outcomes, including death, and it exhibits abuse liability.
  • Preclinical studies suggest MXE possesses antidepressant and analgesic properties, contrasting with its known risks.

Purpose of the Study:

  • To review and synthesize findings on the adverse effects and potential therapeutic benefits of Methoxetamine (MXE).
  • To compile data on MXE's toxicity, psychotomimetic effects, abuse liability, and therapeutic properties.
  • To discuss the mechanisms underlying MXE's paradoxical psychopharmacological effects.

Main Methods:

  • Literature review of preclinical and clinical studies on Methoxetamine (MXE).
  • Compilation of data on toxicity, psychotomimetic effects, abuse liability, and therapeutic actions.
  • Analysis of proposed mechanisms of action for MXE's effects.

Main Results:

  • MXE is associated with significant risks, including toxicity, psychotomimetic effects, and abuse potential.
  • Evidence suggests MXE may have antidepressant effects via glutamatergic and serotonergic systems.
  • Analgesic properties of MXE have also been reported in preclinical studies.

Conclusions:

  • Methoxetamine (MXE) presents a complex profile with both significant risks and potential therapeutic applications.
  • Understanding the mechanisms of action is crucial for evaluating MXE's dual psychopharmacological properties.
  • This review provides a foundation for future research into MXE's therapeutic and adverse effects.
Keywords:
Abuse liabilityAntidepressantIntoxicationMethoxetamine

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