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Author Spotlight: Novel Assay for Studying B-Cell Responses in Multiple Sclerosis Research
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Distinct roles for Blimp-1 in autoreactive CD4 T cells during priming and effector phase of autoimmune

Saba I Aqel1, Marissa C Granitto2, Patrick K Nuro-Gyina3

  • 1Department of Neurology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Journal of Neuroimmunology
|October 27, 2018
PubMed

B lymphocyte-induced maturation protein (Blimp-1) is a transcription factor that regulates effector/memory B cells and CD8 T cells. Here we show that Blimp-1 is expressed in both Th1 and Th17 cells in vitro and highly expressed in effector/memory myelin-specific CD4 T cells in experimental autoimmune encephalomyelitis (EAE) mice. The immunized Blimp-1 conditional knockout mice have a significantly delayed disease onset but enhanced disease severity during the effector phase compared to their wild-type littermates, suggesting that Blimp-1 is a unique transcription factor with distinct roles in the regulation of myelin-specific CD4 T cells during priming and effector phase of EAE.

Keywords:
B lymphocyte-induced maturation protein (Blimp-1)Multiple Sclerosis (MS)Th1Th17experimental autoimmune encephalomyelitis (EAE)

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