Related Experiment Video
Updated: Feb 3, 2026

Electroporation of Craniofacial Mesenchyme
Published on: November 28, 2011
Genetic variants in ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns
Arthur Cunha1, Paulo Nelson-Filho1, Guido Artemio Marañón-Vásquez1
1Department of Pediatric Dentistry, School of dentistry of Ribeirão Preto, University of São Paulo. Avenida do Café s/n - Campus da USP, Ribeirão Preto, SP, Brazil - CEP: 14040-904.
Objective:
This study aimed to evaluate the association of genetic variants inACTN3 and MYO1H with craniofacial skeletal patterns in Brazilians.
Design:
This cross-sectional study enrolled orthodontic and orthognathic patients selected from 4 regions of Brazil. Lateral cephalograms were used and digital cephalometric tracings and analyzes were performed for craniofacial phenotype determination. Participants were classified according to the skeletal malocclusion in Class I, II or III; and according to the facial type in Mesofacial, Dolichofacial or Brachyfacial. Genomic DNA was extracted from saliva samples containing exfoliated buccal epithelial cells and analyzed for genetic variants inACTN3 (rs678397 and rs1815739) and MYO1H (rs10850110) by real-time PCR. Chi-square or Fisher's exact tests were used for statistical analysis (α = 5%).
Results:
A total of 646 patients were included in the present study. There was statistically significant association of the genotypes and/or alleles distributions with the skeletal malocclusion (sagittal skeletal pattern) and facial type (vertical pattern) for the variants assessed inACTN3 (P < 0.05). For the genetic variant evaluated in MYO1H, there was statistically significant difference between the genotypes frequencies for skeletal Class I and Class II (P < 0.05). The reported associations were different depending on the region evaluated.
Conclusion:
ACTN3 and MYO1H are associated with sagittal and vertical craniofacial skeletal patterns in Brazilian populations.
Related Concept Videos
Histone Variants at the Centromere
Classification of Skeletal Muscle Fibers
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
Vertical Curve: Problem Solving
Introduction to Vertical Curves
Types of Genetic Transfer Between Organisms
Genetics of Speciation

