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Updated: Feb 3, 2026

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

43.2K

Targeted Nanomedicine to Treat Bone Metastasis

Isaac M Adjei1, Madison N Temples2, Shannon B Brown3

  • 1J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville 32611, FL, USA. adjeii@ufl.edu.

Pharmaceutics
|October 28, 2018
PubMed

Insights

Nanomedicines offer a promising approach to treat bone metastases from solid tumors, improving drug delivery to bone and reducing side effects. This review explores current nanomedicine strategies for bone metastases and their impact on skeletal-related events.

Area of Science:

  • Oncology
  • Nanotechnology
  • Pharmacology

Background:

  • Bone metastases are frequent complications of prostate, breast, and lung cancers.
  • Skeletal-related events (SREs) like fractures and nerve compression significantly impact patient quality of life.
  • Current treatments for bone metastases are often palliative and lack efficacy due to poor drug penetration and systemic toxicity.

Purpose of the Study:

  • To review the current advancements in nanomedicine for treating bone metastases.
  • To explore novel nanomedicine-enhanced treatment modalities for bone metastases.
  • To discuss the impact of nanomedicines on SREs and cancer progression.

Main Methods:

  • Literature review of nanomedicine applications in bone metastasis treatment.
  • Analysis of nanomedicine characteristics relevant to bone targeting.
  • Discussion of emerging nanomedicine-based therapeutic strategies.

Main Results:

  • Nanomedicines demonstrate potential for enhanced drug targeting to bone metastases.
  • Tunable properties of nanomedicines can improve therapeutic concentrations in bone.
  • Reduced side effects on healthy tissues are achievable with targeted nanomedicine delivery.

Conclusions:

  • Nanomedicines represent a significant advancement in the treatment of bone metastases.
  • Targeted drug delivery via nanomedicine can improve outcomes and reduce SREs.
  • Further research into nanomedicine modalities holds promise for effective bone metastasis management.
Keywords:
active targetingbone marrowdrug deliverynanoparticlepassive targeting

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