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Updated: Feb 3, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE
Published on: May 31, 2013
Statistical shape model-based prediction of tibiofemoral cartilage
Christophe Van Dijck1,2, Roel Wirix-Speetjens2, Ilse Jonkers3
1Biomechanics Section, Mechanical Engineering, KU Leuven, Leuven, Belgium.
Abstract:
Computed tomography is used more routinely to design patient-specific instrumentation for knee replacement surgery. Its moderate imaging cost and simplified segmentation reduce design costs compared with magnetic resonance (MR) imaging, but it cannot provide the necessary cartilage information. Our method based on statistical shape modelling proved to be successful in predicting tibiofemoral cartilage in leave-one-out experiments. The obtained accuracy of 0.54 mm for femur and 0.49 mm for tibia outperforms the average cartilage thickness distribution and reported inter-observer MR segmentation variability. These results suggest that shape modelling is able to predict tibiofemoral cartilage with sufficient accuracy to design patient-specific instrumentation.
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