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Targeting SOX2 in anticancer therapy

Laura Hüser1, Daniel Novak1, Viktor Umansky1

  • 1a Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology , University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg , Mannheim , Germany.

Expert Opinion on Therapeutic Targets
|October 28, 2018
PubMed
Abstract

Insights

SOX2, a key transcription factor, drives cancer progression and therapy resistance. Targeting SOX2 or its regulators offers a promising strategy for novel cancer treatments.

Area of Science:

  • Oncology
  • Molecular Biology
  • Stem Cell Research

Background:

  • SOX2 is a crucial transcription factor for stem cell maintenance.
  • SOX2 promotes cancer cell migration, invasion, and proliferation.
  • SOX2 expression in cancer stem cells correlates with resistance to therapies.

Purpose of the Study:

  • To review the role of SOX2 in cancer progression.
  • To summarize SOX2's involvement in anticancer therapy resistance.
  • To discuss SOX2 as a therapeutic target in oncology.

Main Methods:

  • Literature review of recent studies on SOX2 in cancer.
  • Analysis of SOX2's function in cancer stem cells.
  • Evaluation of therapeutic strategies targeting SOX2.

Main Results:

  • SOX2 significantly contributes to cancer development and metastasis.
  • SOX2 is implicated in the resistance of cancer cells to various treatments.
  • SOX2 presents a viable, yet challenging, therapeutic target.

Conclusions:

  • SOX2 is a critical factor in cancer progression and treatment resistance, making it an attractive therapeutic target.
  • Directly targeting SOX2 is challenging due to its nature as a transcription factor.
  • Identifying and targeting SOX2 upstream or downstream regulators is a key future direction for cancer therapy.
Keywords:
CancerSOX2resistancetherapeutic targetstherapy resistancetumor

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