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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Targeting SOX2 in anticancer therapy.

Laura Hüser1, Daniel Novak1, Viktor Umansky1

  • 1a Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology , University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg , Mannheim , Germany.

Expert Opinion on Therapeutic Targets
|October 28, 2018
PubMed
Summary
This summary is machine-generated.

SOX2, a key transcription factor, drives cancer progression and therapy resistance. Targeting SOX2 or its regulators offers a promising strategy for novel cancer treatments.

Keywords:
CancerSOX2resistancetherapeutic targetstherapy resistancetumor

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Area of Science:

  • Oncology
  • Molecular Biology
  • Stem Cell Research

Background:

  • SOX2 is a crucial transcription factor for stem cell maintenance.
  • SOX2 promotes cancer cell migration, invasion, and proliferation.
  • SOX2 expression in cancer stem cells correlates with resistance to therapies.

Purpose of the Study:

  • To review the role of SOX2 in cancer progression.
  • To summarize SOX2's involvement in anticancer therapy resistance.
  • To discuss SOX2 as a therapeutic target in oncology.

Main Methods:

  • Literature review of recent studies on SOX2 in cancer.
  • Analysis of SOX2's function in cancer stem cells.
  • Evaluation of therapeutic strategies targeting SOX2.

Main Results:

  • SOX2 significantly contributes to cancer development and metastasis.
  • SOX2 is implicated in the resistance of cancer cells to various treatments.
  • SOX2 presents a viable, yet challenging, therapeutic target.

Conclusions:

  • SOX2 is a critical factor in cancer progression and treatment resistance, making it an attractive therapeutic target.
  • Directly targeting SOX2 is challenging due to its nature as a transcription factor.
  • Identifying and targeting SOX2 upstream or downstream regulators is a key future direction for cancer therapy.