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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI
Published on: November 27, 2019
Meta-analysis of functional subdivisions within human posteromedial cortex
Yuefeng Huang1, Jeffrey Hullfish1, Dirk De Ridder2
1Lab for Clinical and Integrative Neuroscience, School of Behavioral and Brain Science, University of Texas at Dallas, 800 W Campbell Rd, Richardson, TX, 75080, USA.
The posteromedial cortex (PMC) has distinct functional regions, including the posterior cingulate cortex (PCC), retrosplenial cortex (RSC), and precuneus (PrC). This study mapped these functions using fMRI data from over 11,000 studies.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
Background:
- The posteromedial cortex (PMC), encompassing the posterior cingulate cortex (PCC), retrosplenial cortex (RSC), and precuneus (PrC), is recognized for its role in the default mode network.
- Specific functions of PMC subregions remain unclear, despite distinct functional profiles.
Purpose of the Study:
- To conduct an unbiased meta-analysis of the PMC using fMRI coactivation and semantic data.
- To disentangle the specific functions of PMC subregions.
Main Methods:
- Utilized Neurosynth to analyze fMRI data from 11,406 studies.
- Performed meta-analysis based on coactivation and semantic information.
Main Results:
- Identified six distinct functional clusters within the PMC.
- These clusters correspond to superior and inferior dorsal PCC, anterior and posterior PrC, ventral PCC, and RSC.
- Each cluster exhibited unique functional profiles.
Conclusions:
- The PMC is functionally heterogeneous, with distinct roles for its subregions.
- Further research is needed to fully elucidate the functional contributions of these PMC clusters.
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