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Related Experiment Video

Updated: Feb 3, 2026

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD
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PTSD and Physical Health.

Annie L Ryder1,2, Patrick M Azcarate2, Beth E Cohen3,4

  • 1San Francisco Veterans Affairs Health Care System, 4150 Clement Street, San Francisco, CA, 94121, USA.

Current Psychiatry Reports
|October 28, 2018
PubMed
Summary
This summary is machine-generated.

Post-traumatic stress disorder (PTSD) is strongly linked to increased risks of cardiovascular, metabolic, and musculoskeletal disorders. Understanding the biological and behavioral mechanisms is crucial for effective treatment and prevention strategies.

Keywords:
Cardiovascular diseaseChronic diseaseComorbidityMechanismsPhysical healthPosttraumatic stress disorder

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Area of Science:

  • Psychiatry and Behavioral Science
  • Internal Medicine
  • Public Health

Background:

  • Post-traumatic stress disorder (PTSD) is a complex mental health condition.
  • Growing evidence links PTSD to a range of physical health problems.
  • Understanding these connections is vital for comprehensive patient care.

Purpose of the Study:

  • To review existing evidence on the association between PTSD and physical health.
  • To explore biological, behavioral, and psychosocial mechanisms underlying these links.
  • To discuss clinical implications of recent research findings.

Main Methods:

  • Systematic review of studies linking PTSD to physical health outcomes.
  • Analysis of evidence for underlying biological, behavioral, and psychosocial mechanisms.
  • Examination of objective measures of disease states where available.

Main Results:

  • Strong evidence links PTSD to increased risk of cardiovascular, metabolic, and musculoskeletal disorders.
  • Alterations in the hypothalamic-pituitary-adrenal axis, sympathetic nervous system, and inflammation are implicated.
  • Few studies have simultaneously measured mechanisms and disease outcomes.

Conclusions:

  • PTSD significantly increases the risk for several physical health disorders.
  • Further research needs to focus on diverse populations and longitudinal studies.
  • Integrating physical health outcomes into PTSD treatment trials is recommended.