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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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[Migraine prophylaxis with a probiotic. Results of an uncontrolled observational study with 1,020 patients]

Andreas Straube1,2, Hilke Müller3, Verena Stiegelbauer3

  • 1Klinik für Neurologie, Oberbayerisches Kopfschmerzzentrum, Klinikum Großhadern, LMU München, München, Deutschland. Andreas.Straube@med.uni-muenchen.de.

MMW Fortschritte Der Medizin
|October 28, 2018
PubMed
Abstract

Insights

A multispecies probiotic formulation significantly reduced migraine frequency and intensity in a study of 1,020 patients. This suggests probiotics may help manage migraine attacks and associated symptoms.

Area of Science:

  • Gastroenterology
  • Neurology
  • Microbiology

Background:

  • Migraine often co-occurs with gastrointestinal disorders like irritable bowel syndrome, inflammatory bowel disease, and celiac disease.
  • These conditions share increased intestinal permeability and elevated inflammatory activity, with pro-inflammatory cytokines potentially triggering migraine attacks.
  • Probiotics may improve gut health and reduce inflammation, offering a potential therapeutic avenue for migraine management.

Purpose of the Study:

  • To investigate the effect of a specific multispecies probiotic formulation on migraine frequency and intensity.
  • To evaluate the impact of the probiotic on migraine-associated complaints and painkiller usage.

Main Methods:

  • An uncontrolled observational study involving 1,020 patients with self-assessed migraine.
  • Patients received a specially formulated multispecies probiotic daily for 8 weeks.
  • Data collected included headache frequency, intensity, associated complaints, and painkiller consumption.

Main Results:

  • A statistically significant reduction in weekly headache days from 2 to 1.4.
  • A significant decrease in headache intensity from 5.1 to 2.1 on a 0-6 scale.
  • Reduced migraine-associated complaints and a 50% reduction in painkiller use were observed.

Conclusions:

  • The studied multispecies probiotic formulation appears to positively influence migraine intensity and frequency.
  • Further confirmation through randomized, placebo-controlled trials is necessary to validate these findings.
Keywords:
leaky gut theorymicrobiomemigraine prophylaxisprobiotic formulation

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