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A Model to Simulate Clinically Relevant Hypoxia in Humans
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[What is clinical relevance?]

Konrad Wink1,2

  • 1Medizinische Fakultät der Universität Freiburg, Arzt für Innere Medizin/Kardiologie, Gengenbach, Deutschland. kwink@t-online.de.

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|October 28, 2018
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Summary
This summary is machine-generated.

Patient-reported outcomes reveal that clinical relevance in treatment is subjective. An average of 41% of patients reported meaningful improvement, varying by condition severity and specific health measures.

Keywords:
analgeticsbootstrap methodclinical relevancehospitaltyimprovement of findingsquality of liferisk factorsstatistical significance

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Area of Science:

  • Medical Research
  • Patient-Reported Outcomes
  • Clinical Significance

Background:

  • Statistical significance does not equate to clinical relevance.
  • Clinical relevance is defined by a patient's perceived improvement.

Purpose of the Study:

  • To determine patient-defined clinically relevant improvements.
  • To analyze the frequency and variability of patient-reported outcomes.

Main Methods:

  • Interviewed 40 patients across six doctor's offices.
  • Collected patient-reported data on satisfactory improvement outcomes.

Main Results:

  • 41% of patients reported clinically relevant improvements on average (95% CI: 24%-57%).
  • Improvements varied significantly based on condition severity, baseline values, and measurement used.
  • Highest reported improvements were for hospitalization (59%) and sleep disturbances (56%); lowest for mobility (33%) and intellectual activity (24%).

Conclusions:

  • Clinically relevant improvements are subjective and depend on individual patient perception.
  • Severely impaired patients often reported minor changes as satisfactory, while mildly impaired patients sought more substantial improvements.