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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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RNA Polymerase (RNAP) is conserved in all animals, with bacterial, archaeal, and eukaryotic RNAPs sharing significant sequence, structural, and functional similarities. Among the three eukaryotic RNAPs, RNA Polymerase II is most similar to bacterial RNAP in terms of both structural organization and folding topologies of the enzyme subunits. However, these similarities are not reflected in their mechanism of action.
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
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Arena-Idb: a platform to build human non-coding RNA interaction networks.

Vincenzo Bonnici1, Giorgio De Caro2, Giorgio Constantino1

  • 1Department of Computer Science,University of Verona, Strada Le Grazie, Verona, Italy.

BMC Bioinformatics
|October 28, 2018
PubMed
Summary

Arena-Idb integrates non-coding RNA (ncRNA) interaction data, aiding researchers in understanding ncRNA functions and their roles in diseases. This platform facilitates the discovery of novel ncRNA roles through network analysis.

Keywords:
Data integrationDatabaseNetworkNon-coding RNA

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • High-throughput technologies enable large-scale genomic analysis.
  • Non-coding RNAs (ncRNAs) are crucial gene regulators and genome maintenance elements.
  • ncRNAs have diverse functions in biological processes and are potential cancer therapeutic targets, but many remain uncharacterized.

Purpose of the Study:

  • To describe Arena-Idb, a platform for retrieving comprehensive and non-redundant annotated ncRNA interactions.
  • To provide a framework for reconstructing networks of ncRNA interactions and their relationships with human diseases.
  • To address data integration challenges in ncRNA research.

Main Methods:

  • Data integration via entity mapping and ambiguity minimization.
  • Network reconstruction of heterogeneous ncRNA interactions.
  • Development of a schema and visualization system for ncRNA interaction data.

Main Results:

  • Arena-Idb offers a unified resource for ncRNA interaction data.
  • The platform facilitates the integration of data from diverse sources.
  • Enables the visualization of complex ncRNA interaction networks.

Conclusions:

  • Arena-Idb aids in discovering ncRNA functions by integrating heterogeneous interaction networks.
  • The platform supports the exploration of ncRNA roles in biological processes and diseases.
  • Arena-Idb is accessible at http://arenaidb.ba.itb.cnr.it.