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Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging
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Directed functional connections underlying spontaneous brain activity.

Ana Coito1,2, Christoph M Michel1, Serge Vulliemoz2

  • 1Functional Brain Mapping Laboratory, Department of Fundamental Neurosciences, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Human Brain Mapping
|October 28, 2018
PubMed
Summary
This summary is machine-generated.

The posterior cingulate cortex (PCC) and medial temporal lobes (MTL) drive spontaneous brain activity. Directed functional connectivity analysis using electroencephalography (EEG) reveals posterior-to-anterior brain interactions.

Keywords:
default-mode networkelectroencephalographygranger causalitygraph theoryresting-state

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Brain Activity Dynamics

Background:

  • Spontaneous brain activity involves dynamic, coherent networks across regions.
  • Directionality of functional interactions in resting-state brain networks is not well understood.

Purpose of the Study:

  • To identify the main drivers and directionality of interactions in spontaneous human brain activity.
  • To apply directed functional connectivity analysis to electroencephalography (EEG) source signals at a whole-brain scale.

Main Methods:

  • Directed functional connectivity analysis applied to EEG source signals.
  • Whole-brain scale examination of electrophysiological activity.

Main Results:

  • Posterior cingulate cortex (PCC), medial temporal lobes (MTL), and anterior cingulate cortex (ACC) identified as main drivers.
  • PCC showed the highest integration and segregation importance, followed by MTL.
  • Effective directed interaction observed from posterior to anterior brain regions.

Conclusions:

  • PCC and MTL structures are key drivers of spontaneous electrophysiological activity.
  • EEG-based directed functional connectivity analysis is a valuable tool for studying brain dynamics.
  • This approach can enhance understanding of brain activity in healthy and disordered states.