Comparing adenoma and polyp miss rates for total underwater colonoscopy versus standard CO₂: a randomized controlled...

Although water exchange may improve adenoma detection compared with CO₂, it is unclear whether water is a better medium to fill the lumen during withdrawal and visualize the mucosa. Total underwater colonoscopy (TUC) involves the use of water exchange with the air valve off during insertion followed by the inspection of the mucosa under water. Our goal was to compare miss rates for TUC with standard CO₂ for polyps and adenomas using a tandem colonoscopy design.

We randomized participants to undergo tandem colonoscopies using TUC or CO₂ first. In TUC, water exchange was performed during insertion, and withdrawal was performed under water. For the CO₂ colonoscopy, both insertion and withdrawal were performed with CO₂. The main outcomes were miss rates for polyps and adenomas for the first examination calculated as the number of additional polyps/adenomas detected during the second examination divided by the total number of polyps/adenomas detected for both examinations. Inspection times were calculated by subtracting the time for polypectomy, and care was taken to keep the times equal for both examinations.

A total of 121 participants were randomized with 61 having CO₂ first. The overall miss rate for polyps was higher for the TUC-first group (81/237; 34%) compared with the CO₂-first cohort (57/264; 22%) (P = .002). In addition, the overall miss rate for all adenomas was higher for the TUC-first group (52/146; 36%) compared with the CO₂ group (37/159; 23%) (P = .025). However, 1 of the 3 endoscopists had higher polyp/adenoma miss rates for CO₂, but these were not statistically significant differences. The insertion time was longer for TUC than for CO₂. After adjusting for times, participant characteristics, and bowel preparation, the miss rate for polyps was higher for TUC than for CO₂.

We found that TUC had an overall higher polyp and adenoma miss rate than colonoscopy performed with CO₂, and TUC took longer to perform. However, TUC may benefit some endoscopists, an issue that requires further study. (Clinical trial registration number: NCT03231917.).