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A compact solvent extraction based 99Mo/99mTc generator for hospital radiopharmacy
Sankha Chattopadhyay1, Sujata Saha Das1, Luna Barua1
1Radiopharmaceuticals Lab., Regional Centre, Board of Radiation & Isotope Technology (BRIT), VECC, 1/AF, Bidhan Nagar, Kolkata 700064, India.
Abstract:
A compact and portable 99Mo-99 mTc generator based on solvent-extraction, mimic to the conventional 99Mo-99 mTc alumina column generator is much-needed commodity for use in hospital radiopharmacy setup. The present study includes the development of a portable, simple and low cost 99Mo/99 mTc-generator based on MEK solvent extraction technique to obtain a very high concentration of no-carrier added (nca) 99 mTc solution, where low specific activity 99Mo source is obtained through 98Mo(n, γ)99Mo reaction in a research reactor. The unit is intended for operation under the conditions of medical radiological laboratories. Technical trials showed that the mean time of preparation of sodium [99mTc] pertechnetate radiopharmaceutical did not exceed 15 min. The quality and yield of 99 mTc-pertechnetate is upto the mark for formulation of radiopharmaceuticals.
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