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Does intratympanic xylitol administration have ototoxic effects in a mouse ear model?
Eda Tuna Yalcinozan1, Ebru Kösemihal2, Mehmet Ates Aksit2
1Department of Otorhinolaryngology, Near East University, Faculty of Medicine, Nicosia, 99138, Cyprus.
International Journal of Pediatric Otorhinolaryngology
|October 29, 2018
Summary
Intratympanic xylitol injections in a mouse model showed no ototoxic effects on the inner ear. Further clinical studies are needed to confirm these findings regarding xylitol
Area of Science:
- Ototoxicology
- Auditory Neuroscience
- Pharmacology
Background:
- Xylitol is a sugar alcohol with various applications.
- Intratympanic injections are used for localized drug delivery to the inner ear.
- Research is needed to assess the safety of xylitol via this administration route.
Purpose of the Study:
- To investigate the potential ototoxicity of xylitol administered intratympanically in a mouse model.
- To evaluate the safety of different concentrations of xylitol in the middle ear.
Main Methods:
- 24 female Balb/c mice were divided into four groups.
- Groups received intratympanic injections of 0.9% NaCl or varying concentrations of xylitol (155, 310, 620 mg/ml).
- Auditory brainstem response tests and microscopic ear examinations were performed before and after injection.
Main Results:
- Statistically significant alterations in auditory threshold values were observed at high frequencies (8000-24000 Hz).
- These changes were independent of xylitol dosage.
- No clear dose-dependent ototoxic effects were identified.
Conclusions:
- Intratympanic xylitol injection did not demonstrate ototoxic effects in the mouse inner ear.
- Further clinical investigations are warranted to fully ascertain the effects of xylitol.
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