Cytological Findings in Benign Phyllodes Tumors

Area of Science:

• Pathology
• Oncology
• Cytology

Background:

• Phyllodes tumors are fibroepithelial breast lesions.
• They share similarities with fibroadenomas.
• Accurate diagnosis is crucial for patient management.

Purpose of the Study:

• To investigate and define the cytological findings in benign phyllodes tumors.
• To differentiate benign phyllodes tumors from other breast lesions.

Main Methods:

• Retrospective analysis of 76 histologically confirmed benign phyllodes tumors.
• Evaluation of cytological criteria: cellularity, epithelial clusters, stromal fragments, and atypia.

Main Results:

• Cytological slides exhibited hypercellularity and dimorphic cell populations.
• Bonsai-like epithelial clusters and oval-to-spindle stromal cells were observed.
• Intranuclear inclusions and popcorn-like nuclei in stromal cells were noted.

Conclusions:

• Stromal hypercellularity, bonsai-like epithelial clusters, and amorphous pinkish material aid diagnosis.
• Intranuclear inclusions and popcorn-like nuclei are novel diagnostic indicators for phyllodes tumors.