Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structural Isomerism02:34

Structural Isomerism

21.7K
Isomerism in Complexes
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
21.7K
Constitutive and Regulated Gene Expression01:27

Constitutive and Regulated Gene Expression

1.2K
Gene expression in prokaryotes is governed by constitutive and regulated systems, allowing cells to balance the production of essential proteins with adaptive responses to environmental changes.Constitutive Gene ExpressionConstitutive, or housekeeping, genes are continuously expressed as they encode proteins vital for fundamental cellular processes. These include enzymes for glycolysis, ribosomal components for protein synthesis, and proteins involved in DNA replication. Their constant...
1.2K
Isomerism02:43

Isomerism

23.3K
Isomers are molecules with the same molecular formula but different structural arrangements. Isomers can be further classified into constitutional isomers and stereoisomers. Constitutional isomers differ in the connectivity of their constituent atoms. For example, 2-butanol and diethyl ether are constitutional isomers, as they have the same chemical formula, C4H10O, but differ in the connectivity of the carbon and oxygen atoms. Constitutional isomers have different physical and chemical...
23.3K
Isomerism in Alkenes02:01

Isomerism in Alkenes

15.0K
Alkenes like 1-butene and 2-butene exhibit constitutional isomerism, as they differ in the position of the double bond. Further, 2-butene exhibits stereoisomerism and exists as two distinct compounds differing in spatial arrangement.
An isomer is called cis-2-butene when the methyl groups are on the same side of the double bond, and the other stereoisomer, in which methyl groups are on the opposite side of the double bond, is called trans-2-butene. The cis and trans stereoisomers are not...
15.0K
Peptide Bonds02:43

Peptide Bonds

83.0K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
83.0K
Constitutional Isomers of Alkanes02:18

Constitutional Isomers of Alkanes

22.3K
Organic compounds of the same molecular formula can have different structural formulas called constitutional isomers, and the phenomenon is known as constitutional isomerism. Alkanes with four or more carbons showing multiple structures with the same molecular formula thereby exhibit constitutional isomerism.
The linear isomer of an alkane is prefixed by the term “n”; hence a linear isomer of pentane is known as n-pentane. Based on the type of branching, some of the...
22.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulating the Swelling Behavior of Polymer Brushes via Interfacial Chemistry.

Angewandte Chemie (International ed. in English)·2026
Same author

Trends and Perspectives in the Targeting of Brain Through Ethosomal Formulations.

Recent advances in drug delivery and formulation·2026
Same author

Stimuli-Responsive Colloidal Gate for Active Modulation of Fluid Flow in Packed Beds.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

Polaritronics: Energy and electron transport through polaritonic states.

The Journal of chemical physics·2025
Same author

Electrospun Polymer Fiber Mats for Persulfide Prodrug Delivery.

Biomacromolecules·2025
Same author

Endothelial Cell Stimulator of Interferon Genes Regulates IL-6 Production and Is Required for Pathologic Cardiac Hypertrophy and Contractile Dysfunction in Experimental Heart Failure.

The American journal of pathology·2025

Related Experiment Video

Updated: Feb 3, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.7K

Self-Assembled Nanostructures Regulate H2S Release from Constitutionally Isomeric Peptides.

Yin Wang1, Kuljeet Kaur1, Samantha J Scannelli1

  • 1Department of Chemistry, Virginia Tech Center for Drug Discovery, and Macromolecules Innovation Institute , Virginia Tech , Blacksburg , Virginia 24061 , United States.

Journal of the American Chemical Society
|October 30, 2018
PubMed
Summary

Researchers developed peptide-hydrogen sulfide (H2S) donor conjugates (PHDCs) that self-assemble into different nanostructures. The nanocoil PHDC demonstrated superior mitigation of doxorubicin cardiotoxicity, showcasing structure-function relationships in H2S-releasing biomaterials.

More Related Videos

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
16:33

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

Published on: April 17, 2014

13.0K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.4K

Related Experiment Videos

Last Updated: Feb 3, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.7K
ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
16:33

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly

Published on: April 17, 2014

13.0K
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
07:26

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

13.4K

Area of Science:

  • Biomaterials Science
  • Supramolecular Chemistry
  • Medicinal Chemistry

Background:

  • Hydrogen sulfide (H2S) is a biological signaling gas with therapeutic potential.
  • Developing controlled H2S delivery systems is crucial for therapeutic applications.
  • Peptide self-assembly offers a platform for creating functional nanomaterials.

Purpose of the Study:

  • To synthesize and characterize peptide-hydrogen sulfide donor conjugates (PHDCs).
  • To investigate the self-assembly behavior and H2S release kinetics of PHDCs.
  • To evaluate the therapeutic efficacy of PHDCs in mitigating doxorubicin-induced cardiotoxicity.

Main Methods:

  • Synthesis of three constitutionally isomeric PHDCs containing glutamic acid and lysine residues functionalized with S-aroylthiooximes (SATOs).
  • Characterization of PHDC self-assembly into different morphologies (nanoribbons and nanocoils) in aqueous solution.
  • Assessment of H2S release rates and their dependence on morphology and SATO decomposition.
  • In vitro evaluation of doxorubicin cardiotoxicity mitigation by different PHDC morphologies.

Main Results:

  • PHDCs self-assembled into distinct nanostructures: two nanoribbons and one nanocoil.
  • H2S release rates varied with morphology; the nanocoil exhibited complex release kinetics.
  • The nanocoil-forming PHDC significantly mitigated doxorubicin cardiotoxicity, outperforming nanoribbon isomers and conventional H2S donors.

Conclusions:

  • PHDCs can be designed to self-assemble into diverse nanostructures with tunable H2S release.
  • Morphology plays a critical role in the H2S release profile and therapeutic efficacy of PHDCs.
  • This study presents a novel strategy for developing advanced H2S-releasing biomaterials with potential therapeutic applications.