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Updated: Feb 3, 2026

Author Spotlight: Eco-Friendly Extraction of Bioactive Compounds Using Polyol-Based Microwave-Assisted Techniques
Published on: August 23, 2024
Phenolic compounds isolated from Morus nigra and their α-glucosidase inhibitory activities
Liangjin Xu1, Meihua Yu2, Lixin Niu1
1Innovation Center of Chinese Medicine, China State Institute of Pharmaceutical Industry, Shanghai, China.
Abstract:
A novel benzofuranone unprecedentedly with a prenyl group at C-3, nigranol A (1), a new flavonol, nigranol B (2), and three known compounds, sanggenon M (3), nigrasin C (4), and nigrasin A (5) were isolated from the twigs of Morus nigra Linn. Their structures were elucidated on the basis of the analysis of multiple spectroscopic data. All of the compounds, along with eight previously isolated ones (6-13) were investigated for their α-glucosidase inhibitory activities. The result showed that compounds 1-13 except 4 exhibited prominent inhibitory activities against α-glucosidase. Among them, compounds 2 and 7 were the best α-glucosidase inhibitory candidates with IC50 values at 1.63 and 1.43 μM, respectively. Furthermore, the structure-activity relationships of the sanggenon-type flavanones were summarized.
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