Related Experiment Video
Updated: Feb 3, 2026

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
Published on: May 10, 2024
Mean Platelet Volume to Lymphocyte Ratio as a Novel Marker for Diabetic Nephropathy
Mehmet Zahid Kocak1, Gulali Aktas1, Edip Erkus1
1Department of Internal Medicine, Abant Izzet Baysal (AIB) University Hospital, Bolu, Turkey.
Objective:
To compare mean platelet volume to lymphocyte ratio (MPVLR) of diabetic nephropathy subjects to those diabetics without diabetic nephropathy.
Study Design:
Observational, cross-sectional study.
Place And Duration Of Study:
Tertiary referral hospital, in Bolu, Turkey, from July to December 2017.
Methodology:
Patients with type 2 diabetes mellitus admitted to the Internal Medicine Clinic, were included. Patients were divided into two groups according to the urinary microalbumin/creatinine ratio: diabetic nephropathy and non-nephropathy group. MPVLR was calculated mathematically by division of MPV by lymphocyte count.
Results:
There were 162 subjects (79 females, 83 males). The MPVLR in patients with diabetic nephropathy and non- nephropathic diabetic groups were 4.1 (2.09-11.84) and 3.4 (1.37-25.56), respectively. The difference was reached statistically significant level (p <0.001). The best cut-off value for MPVLR was 3.66 (AUC=0.733, p <0.001); MPVLR predicted diabetic nephropathy with 71.1% sensitivity and 67.4% specificity, at this level.
Conclusion:
The MPVLR is an easily calculated and efficient index that can be considered a powerful and independent predictor of diabetic nephropathy in diabetic patients. We suggest that, it can be useful adjunct to standard tests in the diagnosis of diabetic nephropathy.
More Related Videos
Related Concept Videos
Poisson's Ratio
Odds Ratio
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Hazard Ratio
For example, in a clinical trial...
The Ratio of X Chromosome to Autosomes
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Transformers with Off-Nominal Turns Ratios

