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Benzodiazepines, plasma MHPG and alpha-2-adrenoceptor function in man.
International Clinical Psychopharmacology
|April 1, 1987
Summary
Benzodiazepine withdrawal may involve increased central noradrenergic activity. This study found that withdrawal from diazepam enhanced plasma MHPG levels and clonidine
Area of Science:
- Neuroscience
- Pharmacology
- Psychiatry
Background:
- Benzodiazepines are commonly prescribed for anxiety and insomnia.
- Withdrawal symptoms can be severe and prolonged.
- The neurobiological mechanisms underlying benzodiazepine withdrawal are not fully understood.
Purpose of the Study:
- To investigate the effects of diazepam administration and withdrawal on central noradrenergic activity.
- To examine the interaction between diazepam and clonidine, an alpha-2 adrenergic agonist, in modulating noradrenergic function.
Main Methods:
- Eight male volunteers received a single dose or a 3-week course of diazepam.
- Plasma MHPG levels and the hypotensive response to clonidine were measured.
- Measurements were taken during diazepam administration and withdrawal.
Main Results:
- Chronic diazepam treatment did not significantly alter plasma MHPG levels but attenuated the clonidine-induced reduction.
- Diazepam withdrawal led to significantly elevated plasma MHPG levels.
- The hypotensive effect of clonidine was enhanced during withdrawal.
Conclusions:
- These findings support the hypothesis that increased central noradrenergic activity contributes to benzodiazepine withdrawal symptoms.
- Diazepam withdrawal may be characterized by heightened sympathetic nervous system activity.
- Further research is needed to explore the therapeutic implications of targeting noradrenergic pathways during benzodiazepine withdrawal.