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[Avermectins, intelligently made in China].

Ying Wen1, Li Xin Zhang2

  • 1State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Yi Chuan = Hereditas
|October 30, 2018
PubMed
Summary
This summary is machine-generated.

Avermectins, derived from microbial fermentation, are vital pesticides and medicines. China

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Area of Science:

  • Biotechnology and Microbial Natural Products
  • Agricultural Science and Food Safety
  • Tropical Medicine and Public Health

Background:

  • Avermectins are fermentation-derived pesticides with high efficacy and low toxicity, crucial for food safety, animal, and human health.
  • Ivermectins, avermectin derivatives, are essential treatments for Onchocerciasis (River Blindness), benefiting over 200 million people in Africa.

Purpose of the Study:

  • To provide an overview of avermectin discovery and development, focusing on basic and applied research.
  • To detail the historical evolution and technological innovation of avermectin production in China.
  • To highlight the impact of Chinese avermectin industry advancements on global supply and microbial drug development.

Main Methods:

  • Review of scientific literature on avermectin discovery and development.
  • Analysis of genetic engineering and technological innovations in microbial production systems.
  • Examination of the historical trajectory and market impact of the Chinese avermectin industry.

Main Results:

  • Significant advancements in understanding microbial production systems for avermectins through genetic engineering in China.
  • Comprehensive technological innovation in the Chinese avermectin industry, leading to substantially improved yield, titer, and productivity.
  • China's emergence as the exclusive global supplier of avermectins, demonstrating successful industrial innovation.

Conclusions:

  • The success of avermectin industry innovation in China offers a model for intelligent yield improvement in other microbial natural product drugs.
  • Chinese advancements in avermectin production have gained international recognition and benefit industrial development of microbial drugs.
  • Continued research and development are crucial for leveraging avermectins and related compounds for global health and agriculture.