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Association Between CHADS2 Score and the Development of Interatrial Block
Jin-Tao Wu1, Xian-Wei Fan1, Hai-Tao Yang1
1Department of Cardiology, Henan Provincial People's Hospital (Zhengzhou University People's Hospital).
Insights
The CHADS 2 score, a measure of stroke risk, is significantly associated with interatrial block (IAB), a heart condition. Higher CHADS 2 scores indicate a greater likelihood of developing IAB, impacting patient risk stratification.
Area of Science:
- Cardiology
- Electrophysiology
- Internal Medicine
Background:
- Interatrial block (IAB) is recognized as a significant predictor of various cardiovascular conditions.
- Understanding factors associated with IAB is crucial for improving patient outcomes and risk assessment.
Purpose of the Study:
- To investigate the potential association between the CHADS 2 score and the development of interatrial block (IAB).
- To determine if the CHADS 2 score can serve as a predictive marker for IAB.
Main Methods:
- Retrospective analysis of 1072 patients.
- Measurement of P-wave duration on 12-lead electrocardiograms to diagnose IAB (P-wave duration ≥ 120 ms).
- Calculation of CHADS 2 scores and multivariate analysis to identify independent predictors of IAB.
Main Results:
- The prevalence of IAB was 36.1% in the study population.
- Increased CHADS 2 score (OR, 1.810), coronary artery disease, and left atrial diameter were independently associated with IAB.
- A significant positive correlation was observed between higher CHADS 2 scores and the presence of IAB, with a notable increase in IAB prevalence for scores ≥ 2.
Conclusions:
- The CHADS 2 score is a significant and independent predictor of interatrial block.
- The findings suggest that the CHADS 2 score can be utilized in the assessment and risk stratification of patients with or at risk for IAB.
Abstract:
Interatrial block (IAB) is associated with a multitude of medical conditions. The aim of this retrospective study was to investigate whether CHADS2 (congestive heart failure, hypertension, age ≥ 75 years, diabetes mellitus, prior stroke) score is positively associated with the development of IAB. A total of 1072 patients (men, 555; women, 517; mean age, 61 ± 14 years) were included in the study. P-wave duration was measured manually using a caliper. IAB was defined as a P-wave duration of ≥ 120 ms on a 12-lead electrocardiogram. CHADS2 scores were calculated retrospectively. Among the 1072 patients, the prevalence of IAB was 36.1% (387/1072). In multivariate analysis, increased CHADS2 score (odds ratio [OR], 1.810; 95% confidence interval [CI], 1.577-2.077; P < 0.001), coronary artery disease (OR, 1.536; 95% CI, 1.065-2.216; P = 0.022), and increased left atrial diameter (OR, 1.039; 95% CI, 1.008-1.071; P = 0.013) were independently associated with IAB. The percentages of patients with IAB among those with a CHADS2 score of 0, 1, 2, 3, 4, 5, and 6 were 20.6%, 33.0%, 45.0%, 55.9%, 61.9%, 77.8%, and 100%, respectively (P < 0.001). There was a greater percentage of patients with a CHADS2 score of ≥ 2 with IAB compared with a CHADS2 score of < 2 (26.5% vsrsus 52.0%; P < 0.001). In receiver operating curve (ROC) analysis, CHADS2 score (area under the curve, 0.670; 95% CI, 0.636-0.704; P < 0.001) was predictive of IAB. In conclusion, CHADS2 score was significantly associated with the development of IAB in this study population.
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