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Updated: Feb 3, 2026
12:40
Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
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Double Dose Plateletpheresis: A Savior to Shrinking Donor Pool and Platelet Inventory Management
R N Makroo1, Dhaval Fadadu1, Soma Agrawal1
1Department of Transfusion Medicine, Molecular Biology and Transplant Immunology, Indraprastha Apollo Hospital, Delhi-Mathura Road, Sarita Vihar, New Delhi, 110076 India.
Summary
Double dose plateletpheresis (DDP) effectively prepares platelets, minimizing infectious risks and donor exposure. This study found DDP safe for donors, with acceptable hematological parameters and mild adverse events, ensuring a reliable platelet supply.
Area of Science:
- Transfusion Medicine
- Hematology
- Apheresis Technology
Background:
- Double dose plateletpheresis (DDP) is a cost-effective method for platelet preparation.
- DDP reduces infectious complications and minimizes allogeneic donor exposure.
- The study evaluates DDP's impact on donor hematology, product quality, and adverse reactions.
Purpose of the Study:
- To assess the feasibility and outcomes of collecting DDP at a center.
- To analyze the effect of DDP on donor hematological parameters.
- To evaluate platelet product quality and donor adverse reactions.
Main Methods:
- Collected 160 DDPs using the Amicus cell separator.
- Monitored donor hematological parameters, product yield, and adverse effects.
- Assessed collection efficiency (CE) and machine collection rate.
Main Results:
- Average yield of 6.14 ± 0.26 × 10^11 platelets per DDP.
- Significant correlation between pre-donation platelet count and yield (p < 0.001).
- Mild citrate-related adverse events in 8.75% of donors; no major adverse effects observed.
Conclusions:
- DDP is a safe procedure with no major adverse effects on donors.
- Post-DDP hematological parameters remain within acceptable ranges.
- DDP enhances apheresis platelet inventory, reduces donor exposure, and lowers product costs.
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