Related Experiment Video

Updated: Feb 3, 2026

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.9K

Traditional Chinese Medicine Syndrome Patterns and Their Association with Hepatitis B Surface Antigen Levels during

He-Ping Xie1,2,3, Zhi-Ping Liu4, Jiong-Shan Zhang1,2

  • 1Department of Integrative Chinese and Western Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.

Evidence-Based Complementary and Alternative Medicine : Ecam
|October 30, 2018
PubMed

Insights

Traditional Chinese Medicine Syndrome (TCMS) patterns change during chronic hepatitis B virus (CHB) infection. Specific TCMS patterns correlate with hepatitis B surface antigen (HBsAg) levels, offering insights into CHB progression and treatment.

Area of Science:

  • Integrative Medicine
  • Hepatology
  • Traditional Chinese Medicine (TCM)

Background:

  • Chronic hepatitis B virus (CHB) infection is a global health concern with a complex natural history.
  • Traditional Chinese Medicine Syndrome (TCMS) patterns are used to categorize patient presentations in TCM.
  • Understanding the relationship between TCMS patterns and viral markers like hepatitis B surface antigen (HBsAg) is crucial for comprehensive patient management.

Purpose of the Study:

  • To investigate the association between TCMS patterns and HBsAg levels throughout the natural history of CHB.
  • To analyze how TCMS patterns evolve across different phases of CHB, including immune tolerance, clearance, low replication, reactivation, cirrhosis, and primary liver cancer.

Main Methods:

  • Categorization of 289 CHB patients into distinct phases of the disease natural history.
  • Classification of patients into five primary TCMS patterns: spleen-kidney deficiency (SKD), liver-qi depression (LQD), damp-heat in liver-gallbladder (LGDH), liver-kidney deficiency (LKD), and blood stasis blocking collateral (BSBC).
  • Statistical analysis of HBsAg levels and other serological indicators in relation to TCMS patterns and CHB phases.

Main Results:

  • TCMS patterns showed statistically significant differences across the various CHB phases (P < 0.001).
  • Predominant patterns varied by disease stage: SKD in the inactive stage, LGDH in the active stage, and BSBC in the advanced stage.
  • Median HBsAg levels differed significantly among TCMS patterns (P < 0.001), with the highest levels in SKD and lowest in LKD and BSBC.

Conclusions:

  • TCMS patterns are dynamic and change during the natural history of CHB.
  • A significant correlation exists between specific TCMS patterns and HBsAg titers.
  • These findings may inform TCM-based therapeutic strategies for managing CHB.

More Related Videos

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders05:34

Author Spotlight: Utilizing Traditional Chinese Acupuncture of the Ear to Improve Sleep Disorders

Published on: August 18, 2023

3.5K
Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

1.1K

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
280
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
5.9K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
244
Traditional Level Of Health Care System01:26

Traditional Level Of Health Care System

The levels of care describe the services provided in the healthcare system. Accordingly, there are six levels of the traditional healthcare system in the US: preventive, primary, secondary, tertiary, restorative, and continuing healthcare. A nurse must understand how the healthcare industry organizes and provides services within these levels of care.
The preventive healthcare service includes tests for screening. Preventive health care services include identifying and reducing disease risk...
3.4K
Hepatic Drug Excretion: Influencing Factors01:16

Hepatic Drug Excretion: Influencing Factors

The biliary system of the liver, crucial for bile secretion and drug excretion, comprises intrahepatic bile ducts that merge to form the common hepatic duct. This duct, carrying hepatic bile, combines with the cystic duct, draining the gallbladder and forming the common bile duct, which empties into the duodenum. Bile, produced by hepatic cells lining the bile canaliculi, is composed primarily of water, bile salts, pigments, electrolytes, and lesser amounts of cholesterol and fatty acids. Bile...
581
Hepatic Drug Clearance: Role of Transporters01:14

Hepatic Drug Clearance: Role of Transporters

In the liver and bile canaliculi, influx and efflux transporters modification can influence intrinsic clearance. Transporters play a significant role in moving drugs within liver cells. Elaborate models, such as the Biopharmaceutical Classification System (BCS), are essential to relate transporters to drug disposition. This system categorizes drugs into four classes based on solubility and permeability, providing insights into elimination routes and the effects of transporters following oral...
309