Therapeutic Apheresis in Metabolic Syndrome

Area of Science:

• Cardiology
• Endocrinology
• Nephrology

Background:

• Metabolic syndrome, characterized by obesity, hypertension, and diabetes, affects 2.5-3.8% of the population and is rapidly increasing.
• It leads to severe complications like stroke, myocardial infarction, retinopathy, nephropathy, and diabetic foot syndrome.
• Existing medical treatments are insufficient to prevent these life-threatening conditions.

Purpose of the Study:

• To explore the potential of plasmapheresis in preventing and treating metabolic syndrome complications.
• To evaluate plasmapheresis as a therapeutic option for metabolic syndrome.

Main Methods:

• A comprehensive review of global literature on metabolic syndrome complications and their treatment modalities was conducted.
• Analysis focused on identifying effective interventions for managing metabolic syndrome sequelae.

Main Results:

• Metabolic syndrome doubles the risk of stroke and myocardial infarction, reducing life expectancy by 5-9 years.
• Microcirculatory damage in diabetes causes retinopathy, nephropathy, polyneuropathy, and diabetic foot syndrome, often requiring lower extremity amputations.
• Plasmapheresis emerged as a primary method for removing pathological metabolites, with own studies confirming its efficacy.

Conclusions:

• Plasmapheresis is a crucial intervention for managing critical conditions associated with metabolic syndrome.
• The application of plasmapheresis should extend to the prevention of metabolic syndrome complications, not just their treatment.