Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

2.2K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.2K
Master Transcription Regulators02:23

Master Transcription Regulators

7.8K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.8K
Epigenetic Regulation01:46

Epigenetic Regulation

33.8K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
33.8K
GTPases and their Regulation02:14

GTPases and their Regulation

9.8K
Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
Large G-proteins,...
9.8K
Regulated Protein Degradation02:58

Regulated Protein Degradation

8.9K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.9K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

26.4K
Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
26.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PCSK5 promotes angiogenesis and cardiac repair after myocardial infarction.

Nature communications·2026
Same author

Hypoxia Upregulation of BACH1 Aggravates Pulmonary Hypertension Through TGFBR2/SMAD Pathways.

Circulation·2026
Same author

LTBP4 deficiency inhibits NLRP3 inflammasome activation in cardiomyocytes and attenuates heart failure in male mice.

Nature communications·2026
Same author

BACH1 recruits STAT3 to enhance leukemia inhibitory factor receptor activity and augments the self-renewal capacity of mouse embryonic stem cells.

Stem cell research & therapy·2025
Same author

The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.

Nature communications·2023
Same journal

Correction to "Lycopene Ameliorates Hypoxic Pulmonary Hypertension via Suppression of Oxidative Stress".

Oxidative medicine and cellular longevity·2026
Same journal

RETRACTION: Acetaldehyde Induces Neurotoxicity In Vitro via Oxidative Stress- and Ca<sup>2+</sup> Imbalance-Mediated Endoplasmic Reticulum Stress.

Oxidative medicine and cellular longevity·2026
Same journal

Correction to "Clinical Significance of Albumin- and Bilirubin-Based Biomarkers in Glaucoma: A Retrospective Case-Control Study".

Oxidative medicine and cellular longevity·2026
Same journal

Interplay of Mitochondrial Dynamics, Nutrition, and Vitamins: Evidence From Experimental and Human Studies With Implications for Women's Health.

Oxidative medicine and cellular longevity·2026
Same journal

Correction to "The Protective Effects of Melatonin on Aluminum-Induced Hepatotoxicity and Nephrotoxicity in Rats".

Oxidative medicine and cellular longevity·2026
Same journal

RETRACTION: Plasma Small Extracellular Vesicle-Carried miRNA-501-5p Promotes Vascular Smooth Muscle Cell Phenotypic Modulation-Mediated In-Stent Restenosis.

Oxidative medicine and cellular longevity·2026
See all related articles

Related Experiment Video

Updated: Feb 3, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.9K

Bach1: Function, Regulation, and Involvement in Disease.

Xinyue Zhang1, Jieyu Guo1, Xiangxiang Wei1

  • 1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Oxidative Medicine and Cellular Longevity
|October 30, 2018
PubMed
Summary
This summary is machine-generated.

The transcription factor Bach1 suppresses gene transcription and regulates key cellular processes like immunity and cancer metastasis. Therapies targeting Bach1 must be specific to cell type and disease state.

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.8K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.4K

Related Experiment Videos

Last Updated: Feb 3, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
12:50

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response

Published on: September 15, 2017

6.9K
Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.8K
In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
06:41

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

14.4K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • BTB and CNC homology 1 (Bach1) is a transcription factor widely expressed in mammalian tissues.
  • Bach1 functions as a transcriptional suppressor by forming heterodimers with small Maf proteins.
  • It binds to Maf recognition elements in gene promoters, regulating various cellular functions.

Purpose of the Study:

  • To review the multifaceted roles of Bach1 in cellular and physiological processes.
  • To summarize Bach1's involvement in reactive oxygen species production, cell cycle, heme homeostasis, hematopoiesis, and immunity.
  • To discuss Bach1's impact on pathological conditions such as ischemic angiogenesis and breast cancer metastasis.

Main Methods:

  • Literature review of studies on Bach1 function and regulation.
  • Analysis of Bach1's molecular mechanisms, including heterodimerization and DNA binding.
  • Synthesis of data on Bach1's physiological and pathological roles across different cell types.

Main Results:

  • Bach1 plays a critical role in regulating reactive oxygen species, cell cycle, heme homeostasis, hematopoiesis, and immunity.
  • Bach1 suppresses ischemic angiogenesis and promotes breast cancer metastasis.
  • Bach1 expression and function exhibit significant variability across different cell types.

Conclusions:

  • Bach1 is a key regulator of diverse cellular and physiological processes with implications in various diseases.
  • Understanding Bach1's cell-type-specific functions is crucial for its therapeutic manipulation.
  • Targeted therapies aimed at modulating Bach1 expression require careful consideration of disease state and cellular context.